SARCOMAS
Vysis LSI EWSR1 (22q12) Dual Color Break Apart Rearrangement FISH Probe Kit
For more information, contact Abbott.
For more information, contact Abbott.
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The Vysis LSI EWSR1 Dual Color Break Apart Rearrangement FISH Probe Kit is intended to detect chromosome rearrangements involving the EWSR1 gene region on chromosome 22q12.
This probe kit is a mixture of 2 FISH DNA probes. The first probe, a 497 kb probe labeled in SpectrumOrange, flanks the 5' side of the EWSR1 gene, and extends inward into intron 4. The second probe, a 1100 kb probe labeled in SpectrumGreen, flanks the 3' side of the EWSR1 gene. The known break points within the EWSR1 gene are restricted to introns 7 through 10.
In an abnormal cell with a simple t(22q12), a one fusion, one green, one orange signal pattern will be expected.
In a normal cell that lacks a t(22q12) in the EWSR1 gene region, a two fusion signal pattern will be observed reflecting the two intact copies of EWSR1.
Normal Hybridization: Result of the hybridization of the Vysis LSI EWSR1 (22q12) Dual Color, Break Apart Rearrangement Probe as observed in a normal interphase cell.
Abnormal Hybridization: An abnormal cell hybridized with the Vysis LSI EWSR1 (22q12) Dual Color, Break Apart Rearrangement Probe. The cell in this image shows the one fusion, one orange, and one green signal pattern indicative of a rearrangement of one copy of the EWSR1 region.
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Please be aware that the website you have requested is intended for the residents of a particular country or countries, as noted on that site. As a result, the site may contain information on pharmaceuticals, medical devices and other products or uses of those products that are not approved in other countries or regions.