Vysis LSI CCND1 (11q13) Dual Color, Break Apart Rearrangement Probe Kit
For more information, contact Abbott.
For more information, contact Abbott.
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The Vysis CCND1 Dual Color Break Apart Rearrangement FISH probe is intended to detect chromosomal rearrangements involving the Cyclin D1 (CCND1) gene region at chromosome 11q13.
The SpectrumGreen probe is located centromeric to CCND1 and spans approximately 695 kb (chr11:68042961-68737635; March 2006 assembly) with an approximately 30 kb gap (chr11:68539031-68568615; March 2006 assembly). The SpectrumOrange probe spans approximately 532 kb (chr11:69162485-69694376; March 2006 assembly)4 and covers CCND1.
The anticipated signal pattern in abnormal cells having a chromosomal breakpoint within the gap between the two probe targets on one chromosome 11 is one orange, one green, and one fusion signal. Other patterns may be observed if additional genetic alterations are present. Hybridization of this probe to interphase nuclei of normal cells is expected to produce two pair of overlapping, or nearly overlapping, orange and green (yellow fusion) signals.
Normal Hybridization: Normal cell hybridization using the LSI CCND1 (11q13) Dual Color Break Apart Rearrangement Probe.
Abnormal Hybridization: Abnormal cell hybridization using the LSI CCND1 (11q13) Dual Color Break Apart Rearrangement Probe.
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Please be aware that the website you have requested is intended for the residents of a particular country or countries, as noted on that site. As a result, the site may contain information on pharmaceuticals, medical devices and other products or uses of those products that are not approved in other countries or regions.