NON-HODGKINS LYMPHOMA
Vysis LSI MALT1 Break Apart FISH Probe Kit
For more information, contact Abbott.
For more information, contact Abbott.
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The Vysis LSI MALT1 Break Apart FISH Probe Kit is intended to detect chromosomal rearrangements at the MALT1 locus on chromosome 18q21 using the fluorescence in situ hybridization (FISH) technique.
The approximately 600 kb (chr18:53915334-54515608; March 2006 assembly, UCSC Genome Browser) SpectrumOrange probe lies centromeric to the MALT1 breakpoint region. The approximately 765 kb (chr18:54554621-55319779; March 2006 assembly, UCSC Genome Browser) SpectrumGreen probe lies telomeric to the MALT1 breakpoint region.
In a normal cell that lacks a t(18q21) in the MALT1 gene region, a two fusion signal pattern will be observed reflecting the two intact copies of MALT1.
In an abnormal cell with a t(18q21), a one fusion, one green, one orange signal pattern will be observed.
Normal Hybridization: Result of the hybridization of the Vysis LSI MALT1 Dual Color Break Apart Rearrangement Probe as observed in three normal interphase cells.
Abnormal Hybridization: An abnormal cell hybridized with the Vysis LSI MALT1 Dual Color Break Apart Rearrangement Probe. The cell in this image shows the one fusion, one orange, and one green signal pattern indicative of a rearrangement of one copy of the MALT1 gene region.
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Please be aware that the website you have requested is intended for the residents of a particular country or countries, as noted on that site. As a result, the site may contain information on pharmaceuticals, medical devices and other products or uses of those products that are not approved in other countries or regions.