CHRONIC MYELOGENOUS LEUKEMIA (CML)
Vysis LSI PDGFRB Break Apart FISH Probe Kit
For more information, contact Abbott.
For more information, contact Abbott.
| PRODUCT NAME | UNIT SIZE | ORDER NUMBER | GTIN |
|---|
The Vysis PDGFRB Break Apart FISH Probe Kit is intended to detect chromosomal rearrangements involving the platelet derived growth factor receptor beta (PDGFRB) gene at chromosome 5q32-q33 using the fluorescence in situ hybridization (FISH) technique.
The approximately 351 kb (Chr5:149100088-149451543, March 2006 assembly)4 SpectrumOrange probe is positioned centromeric to the PDGFRB gene. The approximately 368 kb (Chr5:149543318-149911781, March 2006 assembly) SpectrumGreen probe is positioned telomeric to the PDGFRB gene.
The expected abnormal pattern of the Vysis LSI PDGFRB Break Apart Rearrangement Probe with a rearrangement involving the PDGFRB gene is one orange, one green, and one fusion signal. Other abnormal signal patterns may occur, and metaphase analysis may be helpful in characterization of such patterns.
The expected normal signal pattern of the Vysis LSI PDGFRB Break Apart Rearrangement Probe is two orange/green fusion signals that may be seen as adjacent orange/green signals slightly separated due to the gap between the two probes.
Normal Hybridization: Vysis LSI PDGFRB Dual Color Break Apart Rearrangement Probe hybridized to normal nuclei containing two fusion (2F) signal pattern.
Abnormal Hybridization: Vysis LSI PDGFRB Dual Color Break Apart Rearrangement Probe hybridized to abnormal nuclei containing one orange, one green and one fusion (1O1G1F) signal pattern and normal nuclei containing two fusion (2F) signal pattern.
Please be aware that the website you have requested is intended for the residents of a particular country or countries, as noted on that site. As a result, the site may contain information on pharmaceuticals, medical devices and other products or uses of those products that are not approved in other countries or regions.
Please be aware that the website you have requested is intended for the residents of a particular country or countries, as noted on that site. As a result, the site may contain information on pharmaceuticals, medical devices and other products or uses of those products that are not approved in other countries or regions.