Vysis ROS1 Break Apart FISH Probe Kit
For more information, contact Abbott.
For more information, contact Abbott.
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The Vysis ROS1 Break Apart FISH Probe Kit uses Fluorescence in situ hybridization (FISH) technology to detect ROS1 gene rearrangements at 6q22 involving the receptor tyrosine kinase (ROS1) gene.
Rearrangement of the ROS1 gene occurs in:
Intended Use
The Vysis ROS1 Break Apart FISH Probe Kit is a qualitative test designed to identify acquired pathogenetic alterations of the ROS1 gene at the 6q22 location via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded (FFPE) human specimens.
ROS1 analysis by FISH is used in conjunction with other clinical and diagnostic information and is not to be used as the sole basis for diagnosis or therapy decisions. This test can be performed manually or in semi-automated format.
Probe Description
This probe kit consists of two fluorophore-labeled DNA probes in TE buffer containing blocking DNA:
The Vysis ROS1 Break Apart FISH Probe Kit consists of two separate probes, located 3' and 5' of the common breakpoint region of the ROS1 gene.
To learn more about Vysis ROS1 Break Apart FISH Probe Kit, please visit: https://www.molecular.abbott/int/en/products/oncology/vysis-ROS1-break-apart-fish-probe-kit
Example of the Rearrangement Signal (Left): The signal pattern observed in a cell line containing the ROS1 rearrangement is represented by at least one green/orange (yellow) fusion signal. In addition, a single green (1G) and a single orange (1O) is also visible (green and orange signals separated by a distance of 1 or more signal diameters).
Example of the Non-Rearrangement Signal (Right): Fused green/orange signals are observed. The signals are either overlapping (appearing as a yellow signal), adjacent or are less than 1 signal diameter apart.
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Please be aware that the website you have requested is intended for the residents of a particular country or countries, as noted on that site. As a result, the site may contain information on pharmaceuticals, medical devices and other products or uses of those products that are not approved in other countries or regions.