For more information, contact Abbott.
For more information, contact Abbott.
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These fluorescence in situ hybridization (FISH) probes are intended to detect the t(8;21)(q21.3;q22) reciprocal translocation involving the RUNX1 and RUNX1T1 gene regions.
The approximately 1.4 Mb SpectrumGreen probe spans the RUNX1 gene (chr21:34452353-35813329; March 2006 assembly, UCSC Genome Browser). The approximately 655 kb SpectrumOrange probe spans the RUNX1T1 gene (chr8:92827265-93482325; March 2006 assembly, UCSC Genome Browser).
In a normal cell without the RUNX1/RUNX1T1 (also called AML1/ETO) fusion gene, two orange signals representing normal copies of RUNX1T1 and two green signals representing normal copies of RUNX1 are observed. In a cell containing the RUNX1/RUNX1T1 fusion gene, one orange (RUNX1T1), one green (RUNX1), and two orange/green (yellow) fusion signals are observed. The fusion signals represent the juxtaposition of the translocated portions of the two gene regions on the der(8) and the der(21). Variant RUNX1/RUNX1T1 signal patterns other than the most commonly observed one orange, one green, and two fusions (1O1G2F), may also occur.
Abnormal Hybridization: Vysis LSI RUNX1/RUNX1T1 Dual Color Dual Fusion Probes hybridized to an abnormal nucleus showing a one orange, one green and two fusion (1O1G2F) signal pattern.
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Please be aware that the website you have requested is intended for the residents of a particular country or countries, as noted on that site. As a result, the site may contain information on pharmaceuticals, medical devices and other products or uses of those products that are not approved in other countries or regions.