Vysis LSI BCR/ABL Dual Color, Dual Fusion Translocation Probe
For more information, contact Abbott.
For more information, contact Abbott.
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Vysis LSI BCR/ABL Dual Color Dual Fusion Probes hybridize to chromosome 22q11.2 (breakpoint cluster region SpectrumGreen) and to chromosome 9q34 (abl oncogene SpectrumOrange). The hybridized probe fluoresces with moderate to bright intensity both in interphase nuclei and on metaphase chromosomes.
A nucleus lacking the t(9;22) translocation will exhibit the two orange, two green (2O2G) signal pattern. In a nucleus containing a simple balanced t(9;22), one orange and one green signal from the normal 9 and 22 chromosomes and two orange/green (yellow) fusion signals, one each from the derivative 9 and 22 chromosomes, will be observed (1O1G2F). In some instances, deletions may occur 3’ of the BCR breakpoint and/or 5’ of the ABL breakpoint resulting in either an ES (extra orange or green) signal pattern or a single fusion pattern.
Abnormal Hybridization: LSI BCR/ABL Dual Color, Dual Fusion Translocation Probe hybridized to a nucleus containing a simple balanced t(9;22). One orange, one green and two orange/green fusion signals are observed (1O1G2F).
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Please be aware that the website you have requested is intended for the residents of a particular country or countries, as noted on that site. As a result, the site may contain information on pharmaceuticals, medical devices and other products or uses of those products that are not approved in other countries or regions.