Vysis LSI IGH/CCND1 XT Dual Color Dual Fusion Probes
For more information, contact Abbott.
For more information, contact Abbott.
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Vysis LSI IGH/CCND1 XT Dual Color Dual Fusion Probes hybridize to chromosome 14q32 (IGH SpectrumGreen) and chromosome 11q13(CCND1 Spectrum Orange). This probe is useful for the detection of the translocation t(11;14)(q13; q32). The hybridized probe fluoresces with moderate to bright intensity both in interphase nuclei and on metaphase chromosomes.
In an abnormal cell containing the t(11;14), one orange (CCND1/MYEOV), one green (IGH), and two fusion signal pattern (der (11) and der (14)) may be observed. Some samples containing the t(11;14) may display signal patterns different than one orange, one green, and two fusions.
In a normal cell that lacks the t(11;14), a two orange and two green signal pattern will be observed reflecting the two intact copies of CCND1/MYEOV and IGH respectively.
Normal Hybridization: A normal interphase cell hybridized with the Vysis LSI IGH/ CCND1 XT Dual Color Dual Fusion Probes. The cell shows the expected two orange (CCND1/MYEOV), two green (IGH) signal pattern.
Abnormal Hybridization: An abnormal interphase cell hybridized with the Vysis LSI IGH/CCND1 XT Dual Color Dual Fusion Probes. The cell in this image shows the one orange (CCND1/MYEOV), one green (IGH), two fusion (der (11) and der (14)) signal pattern indicative of a t(11;14).
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Please be aware that the website you have requested is intended for the residents of a particular country or countries, as noted on that site. As a result, the site may contain information on pharmaceuticals, medical devices and other products or uses of those products that are not approved in other countries or regions.