Vysis LSI MYC (8q24.12-q24.13) SpectrumOrange Probe

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Vysis LSI MYC (8q24.12-q24.13) SpectrumOrange DNA probe hybridizes to the band region 8q24.12 - q24.13 of human chromosome 8. The hybridized probe fluoresces with bright intensity in both interphase nuclei and on metaphase chromosomes. In interphase nuclei of normal cells, the probe generally appears as two distinct signals. It may also appear as three or four signals depending upon the condensation of the DNA and the relative distances between chromatids. The signals may also appear diffuse or split. In a normal metaphase, the probe may appear as one or two signals on each chromosome 8.

 

In a cell with amplification of the C-MYC locus,multiple copies of the orange signal may be seen when hybridized with the C-MYC probe.

Normal Hybridization: LSI C-MYC Probe hybridized to a cell. Multiple orange signals are visible.